Paramedics were called to Brettell Lane, near the junction with Crescent Avenue, at 11.59pm last night (Wednesday).
A West Midlands Ambulance Service spokeswoman said: “Sadly, upon arrival, it quickly became apparent to ambulance staff that nothing could be done to save one man in the car and he was confirmed dead.
“The second occupant, a man, sustained multiple serious injuries and was trapped."
The man was removed from the car but despite the best efforts of medics, he died after his condition rapidly deteriorated at the roadside.
One of the men has been named on social media as Karl "Pigeon" Green.
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